More than half of New Chemical Entities (NCEs), which were developed recently, tend to show high crystallinity and poor solubility in water. Solid dispersion is a technique to improve the solubility and bioavailability of these NCEs.…

Drug solubility is a persistent challenge in pharmaceutical product development. The objective of this research is to develop a formulation/processing strategy by means of a biodendrimeric solid dispersion (BDSD) platform, for increasing…

Pharmaceutical research, whether industrial or academic, has attempted to adopt approaches most efficient for the development of innovations. With the abundance of literature and growth of modern techniques available to minimize the…

Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver. Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) technique could be utilized for…

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray…

Mefenamic acid, a BCS class II drug, displays high permeability and low solubility, thereby exhibiting a poor dissolution profile. Hence to improve the solubility and dissolution rate of Mefenamic acid, Hot Melt Extrusion (HME) technique…

The aim of this study was to develop ibuprofen dry suspensions using hot melt extrusion to improve the in vivo performance of ibuprofen. Ibuprofen was melt-extruded into solid dispersions with hydroxypropylmethylcellulose (HPMC) and…

Hot melt extrusion (HME) has been used to prepare solid dispersions, especially molecularly dispersed amorphous solid dispersions (ASDs) for solubility enhancement purposes. The energy generated by the extruder in the form of mechanical and…

Loperamide, an over the counter anti-diarrheal drug, also infamously referred to as “poor man's methadone”. Due to the ease of availability and low price, people/patients abuse it by consuming more than 30 tablets to achieve euphoric…

On Thursday, August 22, 2019 Merck holds a webcaston the topic of Hot melt extrusion with PVA: A new opportunity for challenging APIs In this webcast, you will learn: about amorphous solid dispersions and their…