Pharmaceutical excipients are no longer considered inert and have been shown to influence the activity of metabolic enzymes and transporters, resulting in altered pharmacokinetics of substrate drugs. In this study, the effect of 25…

This work aimed to map and discuss tablet-coating choice, quality deviations of this process, and corrective actions taken by Research and Development (R&D) teams from pharmaceutical industries. Methods A cross-sectional study of…

04. August 2018 Because of polycationic auxiliary agents such as chitosan, polyethyleneimine and cell-penetrating peptides as well as cationic lipids assembling to polycationic systems, drug carriers can tightly…

Thixotropic gels, thermosoftened systems, and self-emulsifying systems have expanded the range of potential excipients. Liquid-filled hard capsules (LFHCs) are typically composed of a shell of gelatin or hydroxypropyl…

02. July 2018 The aim of this study was to develop self-nanoemulsifying drug delivery system (SNEDDS) of bosentan using quality by design (QBD) approach with better bioavailability. The major component of the…

Gelucire® is Gattefossé’s brand of semi-solid excipients originally designed for hard gelatin capsule molding. The name results from the fusion between « gélule » meaning capsule and « cire » meaning wax. Following the name, there is a set…

12. April 2018 PURPOSE: The oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid…

04. April 2018 During the development of parenteral dosage forms, different physicochemical studies are required to ensure stable, effective and safe formulations. The…