High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in…

Granulation is a typical unit operation of particle enlargement carried out by the pharmaceutical industry to produce pharmaceutical dosage forms like tablets and capsules for over 70 years (Parikh, 2009). The purpose of wet …

Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult…

The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality bydesign (QbD) approach. The drug release rate…

07. July 2018 “If formulation science is the Cinderella of drug development, then excipients are the Cinderellas of formulation science”. R. C. Moreton, Finn Brit Consulting This chapter assumes some…

A practical guide to Quality by Design for pharmaceutical product development (This book also includes a chapter on the role of excipients in QbD written by Brian Carlin.) Pharmaceutical Quality by Design: A Practical…

13. November 2017 Parenteral administration of Busulfan (BU) conquers the bioavailability and biovariability related issues of oral BU by maintaining the plasma drug…

09. November 2017 This study applied the concept of Quality by Design (QbD) to tablet dissolution. Its goal was to propose a quality control strategy to model dissolution testing of solid oral dose products…