Background Chlorogenic acid, a phenolic derivative, shows excellent pharmacological properties. However, poor lipidic solubility, permeability, and oral bioavailability restrict its clinical use. Therefore, two different…

Abstract Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy,…

A library of 16 lipid nanoparticle (LNP) formulations with orthogonally varying lipid molar ratios was designed and synthesized, using polyadenylic acid  as a model for mRNA, to explore the effect of lipid composition in LNPs on (i) the…

Abstract Amphiphilic cyclodextrin derivatives (ACD) are useful starting materials for nanomedicines; however, their synthesis using enzymatic catalysis is unsatisfactory. This work focuses on a robust alternative pathway using mineral base…

Psoriasis, a common immune-mediated chronic inflammatory disease, may arise from genetic, epigenetic, and immune system factors. Current medications focus on symptom relief, presenting a challenge in discovering new compounds or methods for…

Lecithin-chitosan nanoparticles (LCNPs) represent an appealing nanocarrier for the oral delivery of hydrophobic drugs. Negatively charged lecithin and positively charged chitosan were permitted to interact to create LCNPs. Their…

Abstract Vaccination has emerged as the most effective strategy to confront infectious diseases, among which is leishmaniasis, that threat public health. Despite laborious efforts there is still no vaccine for humans to confront…

Lipoid is dedicated to continuously optimizing its production processes and product portfolio. For their product LIPOID PE 18:1/18:1 (DOPE), they are now launching a new product quality. The new product quality allows rapid and complete…

Abstract Imiquimod (IMQ) is an immunostimulating agent used in the treatment of basal cell carcinoma and actinic keratosis. Due to its low solubility and poor skin bioavailability, the dermal formulation of IMQ remains challenging. In…