05. July 2017 In this poster, Merck evaluate a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application… More than 80 % of current…
09. January 2017 Abstract The purpose of this study was to compare the chemical and physical stability of amorphous solid dispersions of Ritonavir formulated with either…
15. December 2016
Abstract
Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using…
21. November 2016
The purpose of this work was the development of a continuous process for manufacturing solid oral dosage forms containing itraconazole (ITZ), a model poorly soluble drug. In order to improve its…
The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as the model drug, by obtaining an amorphous solid dispersion by hot melt extrusion. Therefore, an initial preformulation…
29. August 2016 Continuous Manufacturing ofPharmaceuticals: Scale-up ofa Hot Melt Extrusion Process Introduction Over the last three decades industrial adaptability has…
20. April 2016 The aim of this study was to formulate face-cut, melt extruded pellets and to optimize hot melt process parameters to obtain maximized sphericity and hardness…
20. January 2016 The flow properties of drug-polymer mixtures have a significant influence on their processability when using techniques such as hot melt extrusion (HME).…