This study introduces an electrostatic dry powder coating process to coat hard gelatin capsules and hydroxypropyl methylcellulose capsules directly in a coating pan to achieve sustained release. The process overcomes many difficulties in…

In this paper, we have studied Wurster Coating operation for the manufacture of modified release (MR) capsule products submitted to FDA as New Drug Applications (NDAs) and Abbreviated New Drug Applications (ANDAs) by using a data-driven…

This paper presents a system, where images acquired with a digital camera are coupled with image analysis and deep learning to identify and categorize film coating defects and to measure the film coating thickness of tablets. There were 5…

The coating is one of the crucial phases in the production of the tablet dosage form with extended-release profiles. Tablet coating has numerous benefits, including disguising the medicine's odor, taste, physicochemical protection, and…

This study was aimed to develop a fixed dose combination (FDC) tablet containing a low dose of evogliptin tartrate (6.87 mg) for immediate release combined with a high dose (1000 mg) of sustained-release (SR) metformin HCl appropriate for…

We investigated the effect of polymers on the cracking of particulate coating layers. Carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA) were used as contrasting polymer additives due to their different surface charges and film…

Enteric coatings are designed to protect active pharmaceutical ingredients (APIs) against untimely release in the stomach. Acid protection of such coatings depends on the coating layer thickness and integrity, which must be determined in an…

In situ calcium pectinate-coated pellets were proposed by applying an alternate coating method to drug-layered pellets to achieve colon-specific drug delivery. Solution layering of metroprolol tartrate, a water-soluble model drug, on inert…

European Food Safety Authority’s (EFSA) updated assessment on the safety of titanium dioxide as a food additive (published in summer 2021) concludes, that concerns about the genotoxicity of TiO2 particles cannot be excluded. As a result,…

The Discrete Element Method (DEM) is commonly used for modeling the flow of particulate materials. Unfortunately, such detailed simulations are computationally very demanding, restricting its use for industrially-scaled processes. The…