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Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Jan 27, 2021

Abstract Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS…

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Effect of Carrier Type and Tween® 80 Concentration on the Silymarin Release from the Solid…

Nov 9, 2020

The following poster was presented first at AAPS PharmSci 360 in October 2020. We had the chance to get a short introduction from the creator Valentyn Mohylyuk as a audio file. PURPOSE Silybin (the active component of Silymarin)…

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Polymers Used in Peyer’s Patch Targeting

Nov 6, 2020

Peyer’s Patches (PPs) consist of transmucosal clusters of lymphoid follicles overlaid with a specialized lymphoepithelium and play an essential role in the initiation of mucosal immune responses in the gut. Regardless of extensive…

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Bigger or Smaller? Size and Loading Effects on Nanoparticle Uptake Efficiency in the Nasal Mucosa

Oct 29, 2020

PLGA nanoparticles hold great promise for nasal administration, but only with careful design will efﬁcient, effective, and safe delivery systems be developed. To better understand the size dependence of nasal epithelial uptake, PLGA…

Silicon Dioxide

Design and In Vitro Evaluation of Solid SEDDS for Breast Cancer Therapy

Sep 1, 2020

Lipid-based drug delivery systems have been used as a useful tool for the formulation of hydrophobic drugs giving us the opportunity to enhance permeation from biological membranes, protecting active ingredients from harsh in vivo…

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Formulating Cannabinoids

Aug 4, 2020

Cannabinoids are challenging APIs to formulate: Being highly lipophilic compounds with low water solubility, cannabinoids need to be solubilized for subsequent absorption in the gastro-intestinal tract With high first-pass…

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Excipients for Solubility and Bioavailability Enhancement

Jun 15, 2020

Active pharmaceutical ingredients (APIs) exhibiting low aqueous solubility or poor intestinal permeability will be associated with poor or variable drug absorption. Lipid-based drug delivery (LBDD) has emerged as a successful approach to…

Gattefossé – Lipid Excipients

Mar 13, 2020

Gattefossé is a leading provider of lipid excipients and formulation solutions to healthcare industries worldwide. We are committed to delivering high quality excipients, technical support and inspiring your formulations. With an in-depth…

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Olanzapine, improvement of biopharmaceutical performance in solid dosage form

Jan 28, 2020

Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia. It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive…

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Novel Drug Approvals for 2019

Dec 30, 2019

Innovation drives progress. When it comes to innovation in the development of new drugs and therapeutic biological products, FDA’s Center for Drug Evaluation and Research (CDER) supports the pharmaceutical industry at every step of the…

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