The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films.…

The objective of this work was to develop taste-masked donut-shaped tablet formulations utilizing fused filament fabrication three-dimensional printing paired with hot-melt extrusion techniques. Caffeine citrate was used as the model drug…

Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to…

The unpalatability of antituberculosis drugs is often cited as a major cause of non-adherence in children, yet limited quantitative taste assessment data are available. The aim of this research was to quantify the bitterness of isoniazid,…

For the first time, isoniazid (INH) bitterness value, threshold, and sensitivity (low, moderate, high, and extremely high) was determined in six human volunteers. INH demonstrated a large range in bitterness sensitivity. The current work…

Developing formulations appropriate for children still remains to be a major formulation challenge for the pharmaceutical scientists as children are different than adults in many aspects of pharmacotherapy, including capabilities for drug…

Recently there has been an increased interest to develop specialised dosage forms that are better suited to specific patient populations, such as paediatrics and geriatrics. In these patient populations the acceptability of the oral…

The bitter taste of caffeine can be a challenge especially in orally dispersible or liquid dosage forms. In both cases a taste masking by coating or encapsulation of the caffeine can be an effective way to achieve the desired result and…

Sanhuang tablets (SHT) had a broad antibiotic spectrum with high efficiency and low toxicity. However, the clinical application was seriously limited by extremely bitter taste. A novel powder coating technology was established to mask…