Parenteral excipients are substances used in the formulation of injectable drugs. They are an important component of parenteral products as they help to stabilize, solubilize, and enhance the delivery of active pharmaceutical ingredients (APIs) to the patient.
Pharma Excipients
Parenteral Excipients
Development of the Composition and Technology for Obtaining a Model of an Injection Form of an…
The indolocarbazole derivative LCS-1269 has a multitarget mechanism of action on tumors and blocks vasculogenic mimicry. The hydrophobic character of LCS-1269 hampers the development of an injectable dosage form (IDF), the need for which was determined in series of in vitro and in vivo…
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Drug delivery systems for thyroid disease treatment: A mini review on current therapies and…
Thyroid hormones play an important role in many metabolic processes in the human body. However, these processes can often be disrupted by an over or underactivity of the thyroid gland which, if undiagnosed or untreated, can result in serious illness. Currently, therapeutic management of an…
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Solving parenteral solubility challenges in the development of oncology therapeutics
It’s no secret that solubility and bioavailability issues continue to challenge formulators and drug developers. Approximately 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of those in reformulation, are poorly water-soluble. (1) Due to…
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Lubrizol Licenses Award-Winning Apisolex™ Excipient to Welton Pharma to Develop a Novel Cancer…
Upwards of 60% of Cancer Drugs Have Solubility Issues, Lubrizol and Welton Aim to Address This Challenge
CLEVELAND, Ohio – June 21, 2023 – The Lubrizol Corporation announces the licensing of its novel excipient polymer technology, Apisolex™ excipient, to Welton Pharma (Welton). The license allows…
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Critical Excipients in Topical and Parenteral Dermatological Formulations: Novel Analytical…
Background & Introduction
Excipients play a crucial role in efficacy, safety and quality of medicinal products. In topical dermatological formulations, often complex excipients of natural or semi-synthetic origin with broad specifications are used (1). In parenteral drug delivery, non-ionic…
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Thiolated polymers: An overview of mucoadhesive properties and their potential in drug delivery via…
Abstract
Thiolated polymers, or thiomers, are a class of polymers that exhibit unique mucoadhesive properties, allowing them to form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This property makes them ideal for developing drug delivery systems (DDSs) for various dry…
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A systematic review of commercial high concentration antibody drug products approved in the US:…
Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique advantage of allowing subcutaneous…
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Parenteral Drugs: Ensuring Sterility and Minimizing Risks During Manufacturing
THE IMPORTANCE OF PARENTERAL DRUGS
Parenteral drugs are infused or injected either intravenously, intramuscularly, or subcutaneously into the body to treat a wide range of diseases and conditions. Injectables are the second fastest growing segment in the drug delivery technology market and are…
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Parenteral Process Guide – Formulation by Merck
Single-use components, excipients, filters and validation services
Reduce risk and increase efficiency with a fully assembled ready-to-use system:
• Let us help you design a process to meet your specific needs.
• What are the risks you are facing?
• What are your set-up and system issues to…
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Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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