Parenteral Excipients

See in the following a part of the company brochure by PMC Isochem PMC Isochem offers Drug Delivery solutions, CDMO services and Active Pharmaceutical Ingredients and intermediates: From development to GMP production of Amphiphilic and hydrophilic polymers for pharmaceutical…
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D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS hase interesting properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in…
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Parenteral formulations are indispensable in clinical practice and often are the only option to administer drugs that cannot be administrated through other routes, such as proteins and certain anticancer drugs - which are indispensable to treat some of the most prevailing chronic diseases worldwide…
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Functional lactide/glycolide polymers play a key role in complex parenteral drug delivery products. They are often referred to as ‘smart’ materials, as their tunability drives the performance of parenteral dosage forms. Using these polymers, formulators can deliberately change drug impact by…
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Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials have been used to formulate LAI products, including lipids and…
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Biotherapeutic development presents a myriad of challenges in relation to delivery, in particular for protein therapeutics. Protein delivery is complicated due to hydrophilicity, size, rate of degradation in vivo, low permeation through biological barriers, pH and temperature sensitivity, as well as…
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Trehalose has been widely studied as a treatment for a variety of human disorders due to its ability to stimulate autophagy. Trehalose, however, is poorly adsorbed and is hydrolyzed in the intestinal mucosa, and oral delivery requires relatively high doses to induce autophagy. The parenteral…
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Development of Level A in vitro-in vivo correlations (IVIVCs) remains challenging for complex long-acting parenterals, such as poly(lactic-co-glycolic acid) PLGA microspheres. The nature of the PLGA polymer excipient has a dominant influence on the performance of PLGA microspheres. These microsphere…
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Poor aqueous solubility of new chemical entities presents various challenges in the development of effective drug delivery systems for various delivery routes. Poorly soluble drugs that are delivered orally may commonly result in low bioavailability and are often subject to considerable food…
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Purpose To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions. Methods The osmolality was measured by freezing point depression and vapor pressure for 11 different polymers and surfactants (PEG 3350, 4000,…
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