Parenteral excipients are substances used in the formulation of injectable drugs. They are an important component of parenteral products as they help to stabilize, solubilize, and enhance the delivery of active pharmaceutical ingredients (APIs) to the patient.
Pharma Excipients
Parenteral Excipients
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
The poor aqueous solubility of many approved drugs and most new chemical entities poses a challenge to drug delivery scientists working in academic and industrial labs. Despite the high pharmacological activity these drugs may have, their limited water solubility leads to poor absorption and…
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PCL-PEG copolymer based injectable thermosensitive hydrogels
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ …
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Novel Bilayer Microarray Patch-Assisted Long-Acting Micro-Depot Cabotegravir Intradermal Delivery…
Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited,…
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Solubilization Strength Characterization of Parenteral Solutions Containing Polysorbate 80 in…
Leaching of chemical constituents from pharmaceutical polymeric contact materials to clinically relevant solutions including process streams, drug products, or body compartments, is a physicochemical process demanding expert analysis to ensure the safety and efficacy of a medicinal or medical…
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Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a number of adverse effects such as anaphylactic shock. This research was aimed to determine the solubility and stability of paclitaxel in the presence of…
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Injectable Liposome Based Supramolecular Hydrogels for the Programmable Release of Multiple Protein…
Directing and manipulating biological functions is at the heart of next-generation biomedical initiatives such as tissue and immuno-engineering. Yet, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times…
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Emulgel Approach to Formulation Development: A Review
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The…
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Pharmaceutical oils for Cannabinoid drug products from ADM-SIO
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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DEVICE DEVELOPMENT – Selecting Drug Delivery Systems for Higher Doses, Higher Viscosities &…
The development of new parenteral biologics with high-volume, high-viscosity formulations (> 1 mL, >15 cP) is triggering the need for devices that can deliver these therapies with the ease, safety, and low injection time required for self-injection.1-3 As these formulations come to market,…
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Development of a technology for producing a stable injectable dosage form of a hydrophobic…
Objective: Development of a technology for production of a stable injectable dosage form (IDF) of indolocarbazole derivative LHS-1269.
Methods: LHS-1269 is an active pharmaceutical ingredient that was synthesized in the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of…
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