PAT

The aim of this research was to develop a process analytical technology (PAT) tool for monitoring the transformation process of the active ingredient ibuprofen into the fast-dissolving salt ibuprofen sodium during the wet granulation process. Two near-infrared (NIR) spectrophotometers, namely…
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Process analysis and monitoring during the manufacturing of the dripping pills are essential. However, research on developing sensor-based technology or process analytical technology (PAT) tools to analyze and monitor the dripping process is minimal. The purpose of this work is to develop a fast and…
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Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that an appropriate combination of process controls…
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Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined process parameters to achieve quality. However, this status quo is costly; and diverges from regulatory exceptions for process robustness. Although…
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Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined process parameters to achieve quality. However, this status quo is costly; and diverges from regulatory exceptions for process robustness. Although…
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Powders are often granulated to improve their flow properties, content uniformity and processability. Dry granulation is increasingly becoming a preferred granulation technique in the pharmaceutical industry because it makes manufacturing and processing of moisture and heat sensitive active…
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29. June 2017 Case Study :  Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology  Process Analytical Technology, or "PAT" is the term given to analytical instruments developed to measure certain attributes of product within…
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