Pharma Excipients
Pellet
Particle agglomeration analysis using PATVIS APA and deep learning
Introduction: Pharmaceutical, chemical, cosmetic, food, and other industries utilize various processes to modify particle properties, where agglomeration of particles occurs either as an accurately controlled process or as an undesired phenomenon. In both cases, real-time estimation of the particle…
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What is the smallest starter pellet for drug layering and coating?
Two weeks ago we created a poll with a high interaction rate in LinkedIn. The question was: "Pellets - How low can you go? What is the smallest size of starter pellets you can start drug loading and coating?". The answer options were "500 micron", "350 micron", "200 micron" and "100 micron".…
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Formulation and process strategies to minimize coat damage for compaction of coated pellets in a…
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage…
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How Cellets’ particle size influences the flow behavior in a Wurster fluid-bed coater
Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial parameters. Additionally, high level of robustness and…
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3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology
Winner of the Pharmaceutics 2021 Best Paper Awards
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small…
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In vitro behavior of dronedarone hydrochloride loaded pellets using vacuum impregnation technique
Pharmaceutical pellets are a versatile and adaptable drug carrier system with pharmacological and technological advantages specific to multiparticulate delivery systems. Depending on their porosity and formulation procedure, a controlled drug release pattern can be achieved using a variety of pellet…
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Modeling the Coating Layer Thickness in a Pharmaceutical Coating Process
Although mechanistic numerical simulations can offer great insights into a process, they are limited with respect to resolved process time. While statistical models provide long-term predictability, determining the underlying probability distributions is often challenging. In this work, detailed…
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ExciPerience 2021- The complete overview and explanation of the new event for pharmaceutical…
What is the ExciPerience?
ExciPerience 2021 was the new virtual event around every aspect of pharmaceutical excipients. ExciPerience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It was the intersection between all the different perspectives…
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In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In…
In this work, sucrose acetate isobutyrate (SAIB) and polylactic co-glycolic acid (PLGA) were used alone or in combination as a matrix-former (MF) to prepare long-acting injectable rivastigmine (RV) in situ-forming microparticles (ISM). RV-ISM were prepared by the emulsification of an internal phase,…
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Material tracking in a continuous direct capsule-filling process via residence time distribution…
Continuous production of pharmaceuticals requires traceability from the raw material to the final dosage form. With that regard, understanding the residence time distribution (RTD) of the whole process and its unit operations is crucial. This work describes a structured approach to characterizing…
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