Pellet

Multiparticulates such as micropellets, pellets, granules and mini-tablets represent modern and innovative technology platforms. Multiparticulates can provide a number of advantages compared with larger-sized monolithic forms such as tablets. Increasing compliance is achieved for children – from…
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Drug layering on starter pellets is a standard technology to achieve multiparticulate dosage forms. The most widely used are still sugar spheres / non-pareils but also neutral pellets made of microcrystalline cellulose such as Cellets are applied. Although not a lot of new starter pellets have come…
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Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the…
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Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to be potentially challenging. Thus, there is a need for non-segregating cushioning agents to mitigate the deleterious effect of the compaction forces. This study was designed to investigate the use of porous…
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This paper presents the output of a workshop held at the 11th Annual Conference of EuPFI (European Paediatric Formulation Initiative), in September 2019 in Malmo, Sweden, on the development of multiparticulates and minitablets as pediatric formulations. The workshop focused on three specific facets…
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The objective of the present study was to develop a pH-sensitive drug delivery system by using polymethylmethacrylate-grafted gellan gum (PMMA-g-GG). PMMA-g-GG was synthesized by free radical polymerization reaction by using redox initiator ceric ammonium nitrate (CAN), and a series of graft…
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The compaction of multiple unit-pellet system (MUPS) tablets poses considerable challenges due to potential compaction-induced damage to the functional polymer coat and segregation of pellets from other excipients during the tableting process. This study was designed to investigate the impact of…
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Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of medicines to children). Following on from this, little is…
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Surfactants can improve the hydrophobicity of poorly water-soluble drugs and increase the stability of microparticles by reducing surface tension. This study describes that surfactant-engineered florfenicol instant microparticles (FIMs) increase bioavailability through a micellar solubilization…
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The multiple-unit sustained-release (MUSR) dosage forms containing numerous sustained-release subunits present a reliable choice for oral formulation of controlled release systems. As a typical MUSR, the metoprolol succinate sustained-release tablet is an advanced system with limited researches…
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