Pharma Excipients
Pellet
A study on the impact of HPMC viscosity grade and proportion on the functional properties of…
The co-processing of multiple excipients is driven by the potential of diversifying the properties and functionality of excipients when they are combined. Bulk freeze-drying-milling is a novel secondary processing approach to develop co-processed excipients. It offers a significant advantage of…
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Dosage form designs for the controlled drug release of solid dispersions
Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersions can be incorporated in general solid dosage…
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Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via…
The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster…
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Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant…
The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the matrix of glyceryl behenate and poloxamer (pore former). The solid-state, morphology, and micromeritics of the microspheres were…
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The crucial effect of water and co-solvent on Liqui-Pellet pharmaceutical performance
Liqui-Pellet is considered to be the next generation oral dosage form. It is highly commercially feasible unlike its predecessor, liquisolid formulation. Liqui-Pellet uses Liqui-Mass system, allowing the formulation to overcome some of the critical drawbacks in liquisolid technology, which persisted…
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Liquisolid pellets: Mixture experimental design assessment of critical quality attributes…
A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied:…
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Fluidized and Spouted Bed for the preparation of directly processable amorphous solid dispersions
One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them as amorphous solid dispersions (ASDs) with a suitable polymer…
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Mechanistic understanding regarding the functionality of microcrystalline cellulose and powdered…
Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization. While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained by either the “molecular-sponge” or the “crystallite-gel”…
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Quality by Design (QbD) approach to optimize the formulation of Multiunit Particulate System (MUPS)
The objective of this study was to develop and evaluate a MUPS formulation intended for treatment digestive tract ulcers.Work involves evaluation of different formulations of esomeprazole magnesium having enteric polymer and plasticizers to understand impact on dissolution.
A three-factor,…
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Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose…
The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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