Pellet

The purpose is to present the application of the acoustic levitation as a model system for a coating process with non-spherical and light particles in the fluidized bed reactor. An acoustic levitator has been used to track a pellet in a contactless position by Raman spectroscopy, while it was…
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Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle…
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Our research group has pioneered the development of liquisolid pellets as a new drug delivery system targeting at the improvement of the dissolution rates of poorly water-soluble drugs, combining the technological and biopharmaceutical advantages of both multiparticulate and liquisolid systems.…
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Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the…
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The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic,…
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In this work, different formulations of alginate beads containing venlafaxine were prepared by ionotropic gelation. The drug was solubilized in a self-emulsifying phase composed of different percentages of Labrasol or Labrafil and tocopherol polyethylene glycol 1000 succinate (TPGS). Beads were…
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Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization. While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained by either the “molecular-sponge” or the “crystallite-gel”…
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The purpose of this study was to develop a new solid paediatric formulation for propranolol hydrochloride (PR). This drug is used to treat various paediatric diseases, and recently received clearance to treat haemangioma. However, PR has a bitter salty taste that does not facilitate high rates of…
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In the current study, once-a-day dual-release pellets of the selective non-steroidal anti-inflammatory drug celecoxib (200 mg) was developed to treat arthritis. Pellets were prepared where a 100 mg celecoxib, located in the outer layer, was released in an immediate-release (IR) pattern, whereas…
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Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern. Previous studies have shown that pellets located at the tablet axial and radial peripheral surfaces were more susceptible to…
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