Pellet

Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug. This study aims to design novel sustained release (SR) supermicro-pellet based dry…
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The general aim of this paper is to study the coating strength of different composite powders with an experimental approach based on mixing energy descriptors derived from linear velocity at the end of paddles. The chosen system is Cellets particles coated with Talc particles, with two size ratios:…
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Pellets with an immobilized enzyme (acetyl- or butyrylcholinesterase) are the up-to-date type of carriers used for the detection of nerve agents (soman, sarin, tabun, VX, Novichok) and other cholinesterase inhibitors such as organophosphate and carbamate insecticides (parathion, malathion). They…
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The potential for zero-order drug-release was evaluated for ethyl cellulose (EC) coated, acetaminophen-layered sugar pellets (Suglets®) of mesh size 18/20 (850–1000 μm). To determine optimal plasticizer/pore-former concentrations for EC films, solvent-cast Aquacoat® ECD (ethyl cellulose…
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Developing formulations appropriate for children still remains to be a major formulation challenge for the pharmaceutical scientists as children are different than adults in many aspects of pharmacotherapy, including capabilities for drug administration, medicine-related toxicity, and taste…
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A coupled CFD-DEM and Monte Carlo approach was developed to investigate coating properties in a Wurster fluidized bed by considering gas flow, particle motion, droplet deposition, and the drying and solidifying of droplets on particle surfaces. Based on the spherical centroidal Voronoi…
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Current study evaluated the processability and characteristics of prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension instead of previously studied API/FA solutions to enlarge the application field of prilling. Metformin hydrochloride (MET) and paracetamol (PAR) were…
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The purpose is to present the application of the acoustic levitation as a model system for a coating process with non-spherical and light particles in the fluidized bed reactor. An acoustic levitator has been used to track a pellet in a contactless position by Raman spectroscopy, while it was…
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The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster…
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The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellet drug layering to extend the drug release. Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
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