Pellet

Particle coating, a taste-masking technique for drugs, is limited by its long manufacturing time, which is caused by the decrease in the spray rate required to prevent particle agglomeration. Mesoporous silica particles, which have a high surface area and pore sizes in the range of 2–50 nm,…
Read More...

There have been many strategies to increase solubility, dissolution rates, and oral bioavailability of fenofibrate such as micronization, nanonization, solid dispersion, and emulsion so far. To our knowledge, only first three technologies have been applied in producing marketed products, and no…
Read More...

In this era of modernization and hectic lifestyles, consumers demand functional foods providing nutrients with physiological and health benefits. Probiotics belong to this in-demand category of functional and nutraceutical foods. Probiotics are selected viable microorganisms, administered in…
Read More...

An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented. Microcrystalline cellulose particles (Cellets) with size dp = 0.57 mm are used as core material. Waterborne coating suspensions with methylene blue as a dye are used and…
Read More...

Thorsten Cech talks at a BASF symposium in Ludwigshafen, Germany about how using a mixture of different pellets with various release kinetics can benefit a formulation. https://www.youtube.com/watch?v=nngoAR8Ayj4 More on BASF
Read More...

This educational booklet from Glatt gives a great insight on the technologies and processes to coat powders, pellets and micropellets. Introduction Fluid bed processes were originally used in chemical process technology. Fluid bed drying saw its first use in the pharmaceutical industry at the…
Read More...

Spherical pharmaceutical pellets are commonly produced by an extrusion-spheronization process. In the spheronizer, the wet cylindrical extrudates are rounded into spheres due to multiple collisions. In order to model this rounding, a suitable contact model, which can predict the dominantly…
Read More...

The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal…
Read More...

Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms. The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it from the undesirable effects of some drugs. There is certain…
Read More...

The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release. Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
Read More...