Pellet

Pellets and micropellets are an important part of the multiparticulates dosage forms. The manufacturing technologies to achieve pellets are versatile. The overview poster shows the different technologies from drug loading to matrix pellets including continuous processes and the characteristics of…
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Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing. The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs). F127 was added to facilitate drug release of EC MPs, and the…
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Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug delivery systems. By sprinkling on soft food vehicles, these…
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In spite of the major advantages that the liquisolid technology offers, particularly in tackling poor bioavailability of poorly water-soluble drugs (i.e., BCS Class II drugs), there are a few critical drawbacks. The inability of a high liquid load factor, poor flowability, poor compactibility,…
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Wurster coater was utilized for coating glass beads with HPMC/PEG. The effects of design and operating parameters on the coating process were evaluated. It was found that the pressure drop decreases when spraying the coating solution into the bed, indicating that spraying prevents the particles…
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Modified-release oral dosage forms are commonly used in pharmaceutics to delay or sustain the release of drugs. Nowadays, they are only marketed as solid dosage forms such as capsules or tablets. Therefore, the development of a liquid oral dosage form with modified-release properties has been…
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Professor Richard Ross from the University of Sheffield explains in this video the problematics of children suffering from adrenal insufficiency and the new treatment developed with the partners in the TAIN project. It is the first successfully developed effective treatment option for the rare…
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Structure reinforcement of porous hydroxyapatite pellets using sodium carbonate as sintering aid: Microstructure, secondary phases and mechanical properties Porous HAP pellets suitable for loading therapeutic agents were prepared using microcrystalline cellulose (MCC) as pore former and sodium…
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Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition Alginate beads are commonly used for protection of probiotics against adverse environmental conditions. However, alginate beads are unable to provide complete cell viability under stringent…
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Solidification of carvedilol loaded SMEDDS by swirling fluidized bed pellet coating Self-(micro)emulsifying drug delivery systems (S(M)EDDS) have emerged as effective vehicles for enhancing bioavailability of poorly water soluble drugs, however solidification of the systems represents a major…
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