Pharma Excipients
Pellet
A QCM-based assay of drug content in Eudragit RS 100-based delivery systems
A specific version of the quartz crystal microbalance method has been proposed for quantitative evaluation of drug content in polymeric drug carrier systems. In this study, ammonio methacrylate copolymer (type B) microparticles and their standard solutions have been prepared and loaded with set…
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Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique
Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs.
The objective of the present study was to develop a…
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Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems
Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems.
Particles are an important part of many dosage forms and viewed as…
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Neutral & functional starter pellets at Vitafoods
Ingredientpharm provides innovative drug carriers by changing the physical properties of existing excipients.We offer our expertise and technology to enhance the performance of APIs - mainly in the field of taste masking but also for easier processing.
Cellets – neutral starter pellets of…
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Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of…
Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints.…
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of…
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The effects of the treatment conditions on the dissolution profile of ethylcellulose coated pellets
Due to the additional particle coalescence in the coating, changes in the dissolution profile occur over time in the formulations coated by aqueous ethylcellulose latex. Dry thermal treatment (DT) of the coating can be used as a prevention of this process. Alternatively, it is advisable to take…
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Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated…
Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from coated pellets. In the present study, the effects of HPC levels and the pH, type, ionic strength and osmolarity of the media on the release…
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Drug Product Development for Older Adults – Multiparticulate Formulations
The multiparticulate drug product concept covering micropellets, pellets,and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with…
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Non-aqueous formulations for ram and screen extrusion-spheronisation
The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a…
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