Pharma Excipients
Pellet
Paliperidone ascending controlled-release pellets with osmotic core and driven by delayed osmotic…
The aim of this work was to develop an ascending controlled-release pellet (ACRP) of paliperidone to improve poor solubility and provide a stable blood drug concentration. The inner core was produced by mixing different ratios of sodium chloride as an osmotic substance and microcrystalline cellulose…
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Influence of Ar plasma treatment on the wetting behavior of pharmaceutical powders
In this study, corn starch and ibuprofen are treated in Argon (Ar) plasma to enhance the wettability of the powders without using any additive or guest particle. The powder and pellets were exposed to the Ar plasma for different time intervals (5–20 min) at optimized pressure and voltage. While the…
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Effects of pharmaceutical processes on the quality of ethylcellulose coated pellets: Quality by…
The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality bydesign (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated…
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Factors influencing the design of a multiparticulate dosing device
26. July 2018
Paediatric specific medicines have become increasingly researched since the introduction of paediatric investigation plan requirements in 2007. Various dosage forms continue to be investigated for their appropriateness for children, including…
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Novel Extended-Release Multiple-Unit System of Imidafenacin Prepared by Fluid-Bed Coating Technique
27. June 2018
The objective of this study was to formulate once-a-day extended-release (ER) pellet system of imidafenacin (IDN), a recently approved urinary antispasmodic agent with twice-a-day dosing regimen. The sugar sphere pellets were firstly layered with IDN and…
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Pellets and Micropellets for multiparticulate dosage forms
26. June 2018
TTC Workshop 16 – 18 OCTOBER 2018 in Binzen Germany
More and more pharmaceutical products are reaching the market as multiparticulate dosage forms, mainly as pellets. The healthcare sector also frequently selects pellets as the optimal marketable form…
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The Gelucire® family – semi-solid excipients by Gattefossé
Gelucire® is Gattefossé’s brand of semi-solid excipients originally designed for hard gelatin capsule molding. The name results from the fusion between « gélule » meaning capsule and « cire » meaning wax. Following the name, there is a set of two figures: the first (eg 44) indicates the melting…
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Measure the coating thickness and characteristics of tablets or pellets
10. June 2018
The focus of the OSeeT are enteric coatings (EC) and modified-release (MR) coatings.
The characteristics of the coating layer are revealed via OSeeT:
Mean coating thickness
→ progress of coating process
Intra-particle and inter-particle…
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Orogenta® ZOR – Controlled release matrix pharmaceutical dosage formulation
15. March 2018 The Orogenta® Technology enables to achieve zero-order release MUPS tablets coating of the embedded multiparticulates. Some key benefits are: Zero-order drug release tablets…
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Pellets: Multiparticulate drug formulations are on the rise
04. March 2018 Owing to the many benefits they offer both manufacturers and patients, the use of pellets in drug formulation has gained popularity in recent years. With manufacturers beginning to improve their…
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