Pharma Excipients
Pellet
A Novel Approach for Dry Powder Coating of Pellets with Ethylcellulose
19. February 2018 The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and…
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Multiple Unit Pellet System (MUPS) based fast disintegrating sustained release tablets for…
17. January 2018 Abstract Controlled release dosage forms are essential in certain dosage regimens where release rate of drug impacts the effectiveness for therapy. In the present study, modified release dosage form of…
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Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion
26. November 2017 Abstract The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and…
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Multiple-Unit Pellet Systems: Production and Applications as Advanced Drug Delivery Systems
22. November 2017 Background and Objective: Single-unit solid oral dosage forms such as tablets and capsules are considered the most common and acceptable form of immediate release systemic drug delivery systems. On the other…
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Omeprazole MUPS®: An advanced formulation solution
Omeprazole is a pro-drug that accumulates in the acid space of the parietal cell where it is transformed to the active state. However the drug has several characteristics which determine its access to this site of action. Omeprazole is a weak base which is stable at neutral pH but decomposes rapidly…
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Multiple Unit Particle Systems (MUPS) – a drug delivery strategy
29. October 2017 In oral drug delivery modified release dosage forms (MRD) plays an important role in regulating the drug delivery to improve the quality of therapy. One excellent technique to formulate MRDs is multiple unit…
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A non-destructive method for the pellet distribution analysis within a MUPS tablets
25. October 2017 Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE…
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Sustained release venlafaxine hcl pellets
11. October 2017 The objective of this study was to formulate, optimize and evaluate sustained release pellets of venlafaxine hydrochloride. Venlafaxine hydrochloride sustained release pellets were prepared by solution layering…
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Oral Time-Controlled Release Etodolac Pellets
21. September 2017 Abstract The objective of this study was to prepare time-controlled release etodolac pellets to facilitate drug administration according to the body’s biological rhythm, optimize the drug’s desired effects,…
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Drug Product Development for Older Adults – Multiparticulate Formulations
23. August 2017 Abstract The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric…
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