Pharma Excipients
Pellet
Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar,and Microcrystalline…
The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of…
Read More...
Read More...
Modified extrusion-spheronization as a technique of microencapsulation for stabilization of choline…
28. October 2015
Introduction: Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as development of fishy odor and discoloration.
Aim: …
Read More...
Read More...
Melt pelletization of alginate: Effects of air pressurization on consolidation and drug release…
Microstructure consolidation of pellets is envisaged to enable a reduction of drug release in early dissolution phase. This study examines the effects of processing air pressure on drug release property of pellets and their mechanistic modifications on the matrices. The pellets were prepared using a…
Read More...
Read More...
Formulation and evaluation of multiparticulate drug delivery systems comprising telmisartan –…
14. July 2015
Telmisartan is poorly soluble in water, and the rate of dissolution, as well as bioavailability, is less. In the present study, an attempt has been made to improve the dissolution of the drug by coating the drug and carrier over sugar pellets. The solubility promoters…
Read More...
Read More...
Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite® – Abstract
In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite(®) was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model compound. The weight of loaded drug corresponded to 30% of the…
Read More...
Read More...
Preparation and characterization of controlled-release doxazosin mesylate pellets using a simple…
Pellets are one of multiparticulate pharmaceutical forms and can offer numerous technical and biopharmaceutical advantages compared with single dose unit formulations, e.g. tablets and capsules. This study aimed at formulation of controlled-release pellets of doxazosin mesylate (DM), a widely used…
Read More...
Read More...
Pharmazeutische Hilfsstoffe – Quality by Design
17. September 2014
The article is in German and about QBD factors in pharmaceutical excipients with example on pellets. If somebody is interested I can check for a translation. The author Gudrun Ding from IPC Dresden will also be present at Powtech Nürnberg Hall 6 booth 111 and at…
Read More...
Read More...