Pellet

Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of formulations capable of delivering the drug to the intestinal…
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Purpose The main objective was to develop and optimize a multiparticulate system of 5-fluorouracil through the Box–Behnken design (BBD) and desirability function and coating of the optimized batch for increased therapeutic efficacy and targeting for the treatment of colorectal cancer. Method It…
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The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of customised medications in small batches. This is particularly helpful for patients who need specific doses or formulations, such as children. Compounding pharmacies seek alternatives to…
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Abstract Purpose The present work was intended to develop the ibuprofen-Kollicoat® MAE 100P delayed-release pellets using hot-melt extrusion technology, which exhibits pH-dependent solubility. Ibuprofen irritates the gastric lining, so its release in the gastric environment is not desired.…
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Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a similar understanding of microcrystalline cellulose (MCC) is…
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Lisinopril (LIS) it is antihypertensive drug, classified as a class III drug with a high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were…
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Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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During the 1700s, antimalarial properties of quinine were first unleashed. British soldiers stationed in India began drinking tonic water to prevent and combat the disease. However, quinine has a pronounced bitter taste; in the 1800s, gin was added to make the tonic more palatable. Later, lemon and…
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Tablets are solid dosage forms containing medicinal substances with or without suitable diluents. They are the most widely preferred form of medication both by pharmaceutical manufacturer as well as physicians and patients. Capsules are solid dosage forms in which drug is enclosed within either a…
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