Pharma Excipients
Pellet
Comparison of 5-ASA layered or matrix pellets coated with a combination of ethylcellulose and…
The aim of this study was to evaluate and optimize the combination of time and pH-dependent polymers as a single coating for the design of the colon-specific drug delivery system of 5-aminosalicylic acid (5-ASA) pellets. 5-ASA matrix pellets with a 70% drug load were prepared by the…
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Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded…
Multi-unit pellet system (MUPS) is of great interest as it is amenable to customization. MUPS comprises multi-particulates, usually as pellets or spheroids, which can be coated with diffusion barrier coatings. One commonly used diffusion barrier coating is the methacrylic acid copolymer, which can…
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Enhanced geranylgeraniol stability and dissolution from self-emulsifying pellets containing the…
The vegetal species sucupira (Pterodon emarginatus Vogel) presents some diterpenes that have anti-inflammatory activities. However, diterpenes are poorly water-soluble compounds. The development of Self-Emulsifying Drug Delivery Systems (SEDDS) allows for obtaining a solid dosage form that maximizes…
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The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of…
The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments,…
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High Drug Loaded Pellets produced by ProCell® Technology
Poster presented at 4th European Conference on Pharmaceutics 20-21 March 2023 | Marseille, France:
Drug loaded pellets were produced by using the ProCell® lab system technology. The aim was to produce highly drug loaded matrix pellets with an API-polymer ratio of approximately 95:5 by using…
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Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS…
Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as…
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Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet…
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusion to mass produce drug products, but making…
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Paediatric Solid Oral Dosage Forms for Combination Products: Improving In Vitro Swallowability of…
There is a growing interest in determining and improving the acceptability of solid oral dosage forms (SODF) in paediatric populations. Combination products can be an interesting solution to combine two active pharmaceutical ingredients. This study shows that binary mixture of paediatric SODF could…
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Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen…
This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was selected as a model drug for this study due to its thermal…
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