Pharma Excipients
Pellet
Webinar: Pellets from fluid bed processes – a smart concept for high(er) potent drug processing
Manufacturing tablets is frequently a multi-step process: weighing, granulation, milling, blending, compression, coating. The efforts to provide a safe work environment for the production staff are considerably reduced when a technology platform like pellets is applied for high potent APIs.…
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ExciPerience – Early Bird sale ends on January 31st
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory. There will be more and new possibilities for personal interaction and different presentation formats than…
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Development and evaluation of nano-formulations for immediate release oral dosage forms of poorly…
Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Zun Huang
Solubility and dissolution rate are essential for the oral absorption and thus bioavailability of…
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A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can pose the risk of tube clogging. Compared to the…
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Insight into tableted pellets by combining X-ray micro-computed tomography and experimental…
Pellets are spherical agglomerated particles used to produce multiparticulate pharmaceutical dosage forms. This study aims to develop a new approach that evaluates the deformation behavior of pellets under compression, by combining tableting data and compression models with X-ray micro computed…
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Relative bioavailability enhancement of simvastatin via dry emulsion systems: comparison of spray…
Comprehensive comparisons of similar lipid based drug delivery systems produced by different technologies are scarce. Spray drying and fluid bed layering technologies were compared with respect to the process and product characteristics of otherwise similar simvastatin loaded dry emulsion systems.…
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Pharmatrans SANAQ® Sugar Spheres and MCC pellet excipients for controlled release
Recent trends have emphasised that multi-particulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric…
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Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate…
Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial challenge. The correlation between the unstable…
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Spray layering of human immunoglobulin G: Optimization of formulation and process parameters
Spray layering is a technique used to apply drug or functional polymers onto carrier beads; in addition, it can be used as an alternative method for protein drying and to layer protein on a multiparticulate delivery system. In this study, the effects of formulation variables and process parameters…
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Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder…
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and…
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