Pharma Excipients
Pellet
Optimization study of combined enteric and time-dependent polymethacrylates as a coating for colon…
Formulation design for colon-specific delivery of 5-aminosalicylic acid (5-ASA) could bring some therapeutic benefits in the treatment of ulcerative colitis (UC).
In the current study, a 32 full factorial design was used to predict optimum coating composed of two enteric (poly methacrylic acid,…
Read More...
Read More...
Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using…
The aim of this study was to gain deeper insight into the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. Pellet starter cores loaded with verapamil HCl (10% loading, 45% lactose, 45% microcrystalline cellulose) were prepared by…
Read More...
Read More...
A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can pose risk of tube clogging. Compared to the administration…
Read More...
Read More...
Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering…
Oral delivery of peptides is a challenge due to their instability and their limited transport and absorption characteristics within the gastrointestinal tract. In this work, we used layering techniques in a fluidized bed dryer to create a configuration in which the active peptide, permeation…
Read More...
Read More...
Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
Read More...
Read More...
Solventless-mixing layering using a high shear mixer for preparing drug pellets: A feasibility study…
Our aim was to investigate the feasibility of mechanical-mixing layering using a high shear mixer, which can produce drug pellets by simply mixing drug crystals and inactive seed particles without the need for solvents or binders. Acetaminophen crystals and microcrystalline cellulose spheres were…
Read More...
Read More...
Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from…
The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on sustained-release formulation using the Liqui-Mass technology. In this…
Read More...
Read More...
Effect of processing conditions and material attributes on the design space of lysozyme pellets…
The present work aimed to investigate the impact of the critical material attributes on the design space of the production of lysozyme pellets with suitable biological and physical properties for the subsequent coating process. The effect of two brands of both lysozyme and conformation stabilizing…
Read More...
Read More...
Formulation and evaluation of sustained release pellets of lornoxicam
Objective: The aim of study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency.
Methods: The sustained release pellets of lornoxicam were prepared by extrusion – spheronization technique using Eudragit RLPO and Eudragit RSPO…
Read More...
Read More...
Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel…
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on the inert cores made of microcrystalline…
Read More...
Read More...