Pharma Excipients
Mineral Oils
Self-emulsifying Drug Delivery Systems and their Marketed Products: A Review
Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs.
SEDDS are isotropic mixtures, consisting of oils, surfactants, and sometimes cosolvents. Designed formulations are used to improve the oral absorption…
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High-throughput screening of excipients with a biological effect
In this study, we develop and apply a high-throughput screening pro- tocol to investigate the activity of non-ionic surfactants, with a broad range of hydrophilic–lipophilic balance values, against ABCB1-mediated efflux transport and ABCC2-mediated efflux transport.
Methods Caco-2 cells were…
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Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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A new melatonin oral delivery platform based on orodispersible films
An innovative delivery system for melatonin, based on the incorporation of solid lipid microparticles in orodispersible films (ODFs) made of maltodextrin, was designed and developed. Lipid microparticles at two different melatonin concentrations (10 and 20% w/w) were produced by the spray congealing…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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