Pharma Excipients
Polyethylene Glycol
Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional…
Formulating low-solubility or low-permeability drugs is a challenge, particularly with the low administration volumes required in intranasal drug delivery. Nanoemulsions (NE) can solve both issues, but their production and physical stability can be challenging, particularly when a high proportion of…
Read More...
Read More...
Solving parenteral solubility challenges in the development of oncology therapeutics
It’s no secret that solubility and bioavailability issues continue to challenge formulators and drug developers. Approximately 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of those in reformulation, are poorly water-soluble. (1) Due to…
Read More...
Read More...
Rational Design of Topical Semi-Solid Dosage Forms – How Far Are We?
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in understanding the driving forces of skin penetration as…
Read More...
Read More...
Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug…
Read More...
Read More...
Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl…
Solubility of the active pharmaceutical ingredient (API) in an oral formulation is critical for absorption from the gastrointestinal (GI) tract and the intended therapeutic effect. Ensuring that an API has the necessary solubility can be challenging for drug developers and formulators. If…
Read More...
Read More...
Oral Bioavailability Enhancement of Docetaxel by Preparation of Freeze-Dried Ternary Solid…
Abstract
Purpose
The poor solubility and permeability of docetaxel have limited its oral delivery. The current study was aimed at formulating the ternary solid dispersion of docetaxel for treatment of breast cancer and evaluating its oral bioavailability.
Methods
The solid dispersions of…
Read More...
Read More...
3D Printing Technology: A New Approach for the Fabrication of Personalized and Customized…
3DP is a computer-aided design with the interesting innovation of prototyping layer-by-layer, creating 3D articles as digital blueprints to accomplish unequaled gracefulness, time protection, and extraordinary assembling ability of pharmaceutical dosage forms. 3D printing technology offers a novel…
Read More...
Read More...
Integrated continuous melt granulation-based powder-to-tablet line: process investigation and…
In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of…
Read More...
Read More...
Development of an ethanol-free salbutamol sulfate metered-dose inhaler: Application of molecular…
Abstract
Introduction
More than fifty years after the commercialization of the Ventolin metered-dose inhaler (MDI), its constituent active ingredient, salbutamol sulfate (SS), remains the most prescribed short-acting beta agonist for the first-line treatment of acute asthma attacks and the…
Read More...
Read More...
Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and…
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of Chagas disease, but long treatment periods at high dosages cause several adverse effects with insufficient activity in the chronic phase. According to these facts, there is a serious need for novel…
Read More...
Read More...