Pharma Excipients
Polyethylene Glycol
Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an…
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression. Research on the solubility of medications in different oils, surfactants, co-surfactants, and solvents has been…
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A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma
Abstract
Melanoma is the most aggressive form of skin cancer, with increasing incidence and mortality rates. To overcome current treatment limitations, a hybrid molecule (HM) combining a triazene and a sulfur L-tyrosine analogue, was recently synthesized, incorporated in long blood circulating…
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Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review
Diabetes Mellitus is characterized by a hyperglycemic condition which can either be caused by the destruction of the beta cells or by the resistance developed against insulin in the cells. Insulin is a peptide hormone that regulates the metabolism of carbohydrates, proteins, and fats. Type 1…
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Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for…
Layer-by-layer (LbL) modification is an effective way to tune the properties of particles. However, the traditional LbL process involves repeated washing steps which are not compatible with nanoparticles with a partial solubility. In this work, we demonstrate the use of a titration method for…
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Development and evaluation of niacinamide transdermal formulation by artificial membrane…
Despite many efforts to improve the transdermal permeability of drugs, most of them are blocked by the skin barrier. Niacinamide (NAC) is a Biopharmaceutics Classification System class I drug with high aqueous solubility and intestinal permeability. Due to the high solubility and intestinal…
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Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of…
In spite of recent progress made in the field of peptide and protein delivery, oral administration of insulin and similar drugs remains a challenge. In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to…
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Comparative Study of Selected Excipients’ Influence on Carvedilol Release from Hypromellose Matrix…
Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from HPMC-based matrix tablets was studied. A…
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The future of mRNA delivery: Advancements in engineering lipid nanoparticles for enhanced…
Messenger RNA (mRNA) has played a crucial role in recent vaccine developments and is at the forefront of much current medical research. Traditionally. the delivery of mRNA systemically via lipid nanoparticles (LNPs) innately results in LNP accumulation in the liver limiting the access to other…
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Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation…
Abstract
Objectives
Polymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential. Otherwise, a stable form of the parent drug will be recrystallized on the dissolving cocrystal surface and/or in the bulk solution during the…
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Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the…
In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better efficacy. Current research reports the development of nanoemulgel (NEG) loaded with ginger…
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