Pharma Excipients
Polyethylene Glycol
Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin
The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various excipients including surfactants, glycerides and waxes, as well as various drug-delivery systems, namely self-emulsifying drug delivery systems (SEDDS), solid…
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Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery systems have been designed to address these issues. One of…
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Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor…
Purpose
To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions.
Methods
The osmolality was measured by freezing point depression and vapor pressure for 11 different polymers and surfactants (PEG 3350, 4000,…
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How to improve topical formulations of poorly-water soluble APIs
Solubility of an Active Pharmaceutical Ingredient (API) in the dosage form is a key parameter in topical formulation. Poor solubility can negatively impact the API drug load, its stability in the dosage form as well as its skin permeation behavior.
Polar solvents such as PEG-400, diethylene…
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Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM…
Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most frequently employed techniques for 3D printing. The aim of…
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Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial…
It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an emulsification and homogenization-extrusion…
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Optimization of a film coating formulation for high solid content application suitable for…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil…
Abstract
Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by…
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3D printed dexamethasone-loaded punctal plugs for dry eye disease
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an…
Chronic inflammation is a significant pathological process found in a range of disease states. Treatments to reduce inflammation in this family of diseases may improve symptoms and disease progression, but are largely limited by variable response rates, cost, and off-target effects. Macrophages are…
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