Pharma Excipients
Polyethylene Glycol
Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed…
The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial…
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FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to investigate the influence of shape and infill percentage on…
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PCL-PEG copolymer based injectable thermosensitive hydrogels
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ …
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In Vitro and In Vivo Studies of a Verapamil-Containing Gastroretentive Solid Foam Capsule
Gastroretentive systems may overcome problems associated with incomplete drug absorption by localized release of the API in the stomach. Low-density drug delivery systems can float in the gastric content and improve the bioavailability of small molecules. The current publication presents…
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Biological fate and interaction with cytochromes P450 of the nanocarrier material, D-α-tocopheryl…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol (PEG) 1000. It is approved by the US Food and Drug Administration (FDA) and has found wide application in…
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Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release…
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in…
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Fabrication of delayed release hard capsule shells from zein/methacrylic acid copolymer blends
Hard capsule shells with an inherent delayed release action are useful for oral administration of active ingredients, which are acid-labile and/or enzymatically degradable in the gastric environment, without the need of film coating. The objective of this study was to fabricate delayed release hard…
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Management and control of intraocular pressure applying macitentan hydrogel film formulation:…
Background
Macitentan blocks endothelin receptors in order to control the pulmonary arterial hypertension (PAH). Oral administration of macitentan is associated with painful urination and troubled breathing.
Objectives
Formulated macitentan hydrogel film was used for examining the control of…
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Excipient Innovation Through Precompetitive Research
The mRNA COVID-19 vaccines developed by Pfizer/BioNTech and Moderna represent a triumph of vaccine development. The core mRNA component of these vaccines is now almost a household name. Unbeknownst to most people, however, is that each of the two mRNA COVID vaccines contains two novel excipients; a…
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Advances in the Treatment of Inflammatory Bowel Disease: Focus on Polysaccharide Nanoparticulate…
The complex pathogenesis of inflammatory bowel disease (IBD) explains the many hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to reduce inflammation during the hot phase or maintain remission during the cold phase. Nonetheless, these drugs suffer from…
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