Pharma Excipients
Polyethylene Glycol
Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and…
Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the continuous phase, limonene as the dispersed phase and a mixture…
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The evolution of commercial drug delivery technologies
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small…
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Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine
On the first day of the UK vaccination campaign with the coronavirus disease 2019 (COVID‐19) vaccine, there were reports of 2 cases of anaphylaxis within minutes of administration of the Pfizer/BioNTech messenger RNA (mRNA) vaccine and a third case of an allergic reaction not requiring adrenaline…
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Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug.
Methods: The nateglinide SD prepared using crospovidone and evaluated for drug content and drug dissolution. The optimized…
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Removal of azithromycin from aqueous bulk solution using water/ethanol/transcutol/capryol-90 green…
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion. The drug is identified as potential pharmaceutical drug for detrimental effect on flora and fauna of aquatic lives and human health. Green…
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Sustained release of peptides and proteins from polymeric nanocarriers produced by inverse Flash…
Peptide and protein therapeutics generally exhibit high potency and specificity and are increasingly important segments of the pharmaceutical market. However, their clinical applications are limited by rapid clearance and poor membrane permeability. Encapsulation of the peptide or protein into a…
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Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation
Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their structure, which have been explored in biomedical…
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Oral delivery of peptide therapeutics in infants: Challenges and opportunities
Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations. Peptide drugs, which have become increasingly relevant in the past several decades, are no exception. Unfortunately, nearly all of the 60+ approved peptide drugs are formulated for…
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Development of poly-L-lysine multi-functionalized muco-penetrating self- emulsifying drug delivery…
Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic ciprofloxacin (CIP)modalities into the intracellular compartments of macrophages owing to poor solubilization and oral bioavailability. Poor penetration and dissolution of CIP lead to development of…
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Size Shifting of Solid Lipid Nanoparticle System Triggered by Alkaline Phosphatase for Site Specific…
We aim to prepare a size-shifting nanocarrier for site-targeting mucosal drug delivery that can penetrate through mucus gel layer and remain close to the absorption membrane. As nanocarriers can be engineered to penetrate mucus but they can also back diffuse into outer mucus regions, a size shifting…
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