Pharma Excipients
Polyethylene Glycol
Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP…
The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populations (age- and disease-dependent), drug and…
Read More...
Read More...
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation…
Three-dimensional printing (3D-printing) is a technology that prints the products layer-by-layer, in which materials are deposited according to the digital model designed by computer aided design (CAD) software. This technology has competitive advantages regarding product design complexity, product…
Read More...
Read More...
Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate…
Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low bioavailability. D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) is approved as a safe pharmaceutical adjuvant with marked antioxidant and anti-inflammatory…
Read More...
Read More...
3DP Printing of Oral Solid Formulations: A Systematic Review
Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their…
Read More...
Read More...
Towards the Development of Long Circulating Phosphatidylserine (PS)- and Phosphatidylglycerol…
The anionic phospholipids (PLs) phosphatidylserine (PS) and phosphatidylglycerol (PG) are endogenous phospholipids with anti-inflammatory and immunomodulatory activity. A potential clinical use requires well-defined systems and for several applications, a long circulation time is desirable.…
Read More...
Read More...
Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production…
Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. At the same time, modern technologies are…
Read More...
Read More...
What are the Ingredients and Excipients in the COVID-19 Vaccines? Update including Novavax Vaccine
What's in a vaccine?
With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are working to develop a vaccine that will protect us against…
Read More...
Read More...
Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid…
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the principal API–carrier non-bonding interactions are critical…
Read More...
Read More...
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption window. In the recent decades, several technologies have evolved…
Read More...
Read More...
Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of…
Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared incorporating different plasticizers and evaluated for in vitro …
Read More...
Read More...