Pharma Excipients
Polyethylene Glycol
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal administration could be used to improve antibiotic delivery for treatment of Mycobacterium tuberculosis infection.…
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Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS diseases, having major role in the protection of the brain but…
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Maintaining Safety with SARS-CoV-2 Vaccines
Review article by Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. in The NEW ENGLAND JOURNAL of MEDICINE
To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with…
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An Investigation into the Relationship between Xanthan Gum Film Coating Materials and Predicted…
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF depends on their shape, size, density, and surface…
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Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral…
Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g., dysphagia) in the older patient population, especially when…
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What are the Ingredients and Excipients in the COVID-19 Vaccines?
Covid-19 vaccination has been a big topic and we were curious on the role of excipients in such formulations. Not surprisingly both Pfizer-BioNTech and Moderna (source FDA) have quite similar compositions: Active Ingredient, Lipids and a saline solution. Lipid (oil) "bubbles" are tiny bubbles of…
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Investigating the influence of various plasticiser on the properties of Kollicoat® SR 30 D based…
INTRODUCTION
Plasticiser play a decisive role in the application of functional films, especially, if an aqueous dispersion containing a water insoluble polymer is used. For the water insoluble sustained release film forming polymer PVAc, both elongation at break and minimum film forming temperature…
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Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug…
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An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery…
Polyethylene glycols (PEGs) and PEG derivatives are used in a range of cosmetic and pharmaceutical products. However, few studies have investigated the influence of PEGs and their related derivatives on skin permeation, especially when combined with other solvents. Previously, we reported…
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