Pharma Excipients
Polyethylene Glycol
3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment
In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) and rifampicin (RFC) for the treatment of tuberculosis. INZ was formulated in hydroxypropyl cellulose (HPC) matrix to allow drug release in the stomach (acidic…
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Thiolated and PEGylated silica nanoparticle delivery to hair follicles
Targeting drug delivery to hair follicles is valuable to treat conditions such as alopecia’s and acne, and this shunt route may also allow drug delivery to deeper skin layers and the systemic circulation by avoiding the intact stratum corneum. Here, we investigated the effects of nanoparticle…
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Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation…
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Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of…
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a…
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Smart liquids for oral controlled drug release: An overview of alginate and non-alginate based…
Sustaining and controlling the rate of drug release is essential in pharmaceutical technology. It can reduce the number of units administered by the patient with subsequent improvement in patient compliance. These technologies can allow controlled liberation of the active pharmaceutical ingredients…
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The progress on sulfhydryl modified polymers with regard to synthesis, characterization and…
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the…
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Insights in the rheological properties of PLGA-PEG-PLGA aqueous dispersions: structural properties…
PLGA-PEG-PLGA are copolymers, able to form temperature-dependent hydrogels or sol dispersions at selective conditions. A general overview about the rheological characterization of their aqueous dispersions, focusing how the structural characteristics (e.g. molecular weight, PEG/PLGA ratio) affect…
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Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.
AIM: The aim of this research was to select a specific brand of…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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3D printing of solid oral dosage forms: numerous challenges with unique opportunities
Since the FDA approval of Spritam, there has been a growing interest in the application of 3D printing in pharmaceutical science. 3D printing is a method of manufacturing involving the layer-by-layer deposition of materials to create a final product according to a digital model. There are various…
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