Pharma Excipients
Polyethylene Glycol
Design, Fabrication & Characterization of Graft Co-Polymer Assisted Ocular Insert: A State of…
Targeted delivery of drugs at appropriate concentrations to ocular tissues is required to avoid wastage. Hence, advanced systems that maximize the release of poorly soluble drugs and deliver them at ocular sites must be designed.
Methods: In this study, Soluplus® (polyvinyl caprolactam–polyvinyl…
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Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction…
Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated therapeutics can induce anti-PEG antibodies (APA), there is…
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Formulation design and pharmacokinetic evaluation of docosahexaenoic acid containing…
Docosahexaenoic acid is a omega-3-fatty acid which together with other long-chain omega-3-fatty acid known to have protective effect against various diseases including hypertension, myocardial infarction, Alzheimer disease, and cancers. Poor bioavailability owning to limited aqueous solubility…
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Enhanced oral bioavailability of Bisdemethoxycurcumin-loaded self-microemulsifying drug delivery…
In this study, we sought to overcome the poor solubility and bioavailability of bismethoxycurcumin (BDMC) by fabricating a BDMC-loaded self micro-emulsifying system (BDMC-SMEDDS). Solubility and compatibility tests, pseudo-ternary phase diagrams (PTPDs) as well as d-optimal concept was applied to…
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Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical…
Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated in polymeric micelles. Polymeric micelles have shown improved…
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New pharmaceutical dosage forms used in the treatment of breast cancer. Polymeric micelles
Among all types of cancer encountered in women, breast cancer is the most prevalent, with the highest mortality rate. An increased survival rate is closely related to early diagnosis, the use of high performing screening methods and of selective and adequate treatments. By using the…
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Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial…
Pharmaceutical 3D-printing represents a potentially new dosing and manufacturing approach for the pharmaceutical industry, with unique opportunities for personalization of dosage strengths. Fused deposition modelling (FDM) is a 3D-printing technique, which presents advantages for decentralized…
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Comparison between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol
Nebivolol (NBH) is a third-generation β1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low…
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Melt Dispersion Adsorbed onto Porous Carriers: An Effective Method to Enhance the Dissolution and…
The objective of the present investigation is to enhance the dissolution and flow properties of raloxifene hydrochloride (RXH), a biopharmaceutical classification system class II drug. Melt dispersion of RXH with polyethylene glycol (PEG) 6000 was prepared by the fusion method. The melt dispersion…
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Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and…
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential…
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