Pharma Excipients
Polyethylene Glycol
The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration of classical tablets due to the increased risk of choking…
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Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of…
Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural…
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Poly(ɛ-caprolactone) and Eudragit E blends modulate the drug release profiles from FDM printlets
Abstract
Thermoplastic polymers have been used to produce filaments by hot melt extrusion (HME), which can be applied to obtain 3D printlets by fused deposition modelling (FDM). Poly(ε-caprolactone) (PCL) is a low melting point thermoplastic polymer that provides HME filaments with excellent…
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Modern Aspects of Suppositories: A Review
ABSTRACT
Suppositories are an underutilized dosage form. Suppositories are such types of dosage forms used to provide medication via the vaginal and rectal routes. Vaginal suppositories are commonly referred to as pessaries. It was
developed from a formulation called Liquid Enema. Enema has a…
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A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic…
Since 1922, insulin has saved the lives of countless people. However, the difficulties of subcutaneous administration, the need for frequent glucose self-monitoring, and the non-physiological action profiles of insulin prompted many medical professionals and patients to ask fornon-injectable insulin…
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Use of Excipients in Downstream Processing to Improve Protein Purification
Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions such as temperature changes, pH changes, or agitation. Similar stresses are applied to proteins during downstream purification. Shifts in pH during Protein A…
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A novel cationic arginine-modified Self-Nanoemulsifying drug delivery system (SNEDDS) for improved…
Abstract
Naringin (NRG) is a flavonoid derived from citrus fruits. Despite its pharmacological significance, NRG's therapeutic effectiveness is constrained by its unusual physicochemical characteristics, such as its lower aqueous solubility. This study was intended to develop an alkylated arginine…
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Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use
Abstract
Background: Prednisolone acetate is an ester form of prednisolone. It is used topically as an ophthalmic suspension to treat many inflammatory ocular conditions, where its absorption from suspension is highly variable and has poor dose accuracy.
Objectives: The main objective of this…
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Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and…
Monoclonal antibodies (mAbs) hold promise for treating Parkinson's disease (PD), but their therapeutic use is hindered by poor delivery to the brain. In this study, we demonstrate that brain-targeted liposomes (BTL) enhance the delivery of mAbs across the blood-brain-barrier (BBB) and into neurons,…
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USP-NF: Proposed Revisions to Polyethylene Glycol Monograph and Call for Stakeholder Feedback
The United States Pharmacopeial Convention (USP) develops and regularly updates USP–NF (United States Pharmacopeia and the National Formular) standards via a distinctive collaborative process that engages pharmaceutical scientists from various sectors, including industry, academia, and government,…
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