Pharma Excipients
Polyethylene Glycol
The role of Eudragit® as a component of hydrogel formulations for medical devices
Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to…
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Development of Osthole-Loaded Microemulsions as a Prospective Ocular Delivery System for the…
Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded microemulsion (OST-ME) was created to improve the drug’s…
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Effect of Moisture Content of Excipient (Microcrystalline Cellulose)
Abstract
Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all ingredients which is used for making the final product tablet.…
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Development and Optimization of a Novel Lozenge Containing a Metronidazole-Peppermint Oil-Tranexamic…
In-depth studies on essential oil–based nanoemulsions (NEs) have centered on a variety of oral health issues. NEs improve the delivery of nonpolar active agents to sites and thereby boost the dissolution and distribution of the agents. Metronidazole-peppermint oil-tranexamic acid…
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Leveraging a multivariate approach towards enhanced development of direct compression extended…
Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to develop extended release formulations is direct compression, which offers…
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Fenofibrate loaded nanofibers based thermo-responsive gel for ocular delivery: Formulation…
This research work is to develop nanofiber loaded in -situ gel for the delivery of fenofibrate to the posterior ocular site. Fenofibrate had showed its efficacy in neovascular ocular diseases under clinical studies but its low aqueous solubility makes difficult to develop a suitable ocular…
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A quality by design framework for developing nanocrystal bioenabling formulations
The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the high-pressure homogenization (HPH) technique. Accordingly, the…
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Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug…
Psoriasis with unclear etiology and pathogenesis is one of the most prevalent chronic skin diseases. It involves excessive keratinocytes cells hyperproliferation, abnormal vascular infiltration, and differentiation as its characteristic features. Patients need therapy on a periodic basis over a long…
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The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS…
Self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations, designed to improve the solubility of poorly-water soluble drugs. Mesoporous silica is frequently used for SMEDDS solidification by various techniques. One of them is wet granulation, which enables achieving both high…
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One Step In Situ Co-Crystallization of Dapsone and Polyethylene Glycols during Fluidized Bed…
Abstract
Several studies have demonstrated the feasibility of in situ co-crystallization in different pharmaceutical processes such as spray drying, hot melt extrusion, and fluidized bed granulation (FBG) to produce co-crystal-in-excipient formulations. However, no previous studies have examined…
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