Pharma Excipients
Propylene Glycol
Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the…
In recent years, the treatment of bacterial skin infections has been considered a major healthcare issue due to the growing emergence of antibiotic-resistant strains of Staphylococcus aureus. The incorporation of antibiotics in appropriate nanosystems could represent a promising strategy, able to…
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Excipients for veterinary application – IOI Oleo
See an overview of the IOI Oleo specialties for Veterinary Applications.
They are used for companion as well as for farm animals in following uses:
• Injectables - SC and IM
• Infusions - IV
• Oral (e.g. paste, drench)
• Pour-on / Spot-on formulations
• Tick and flea collars
…
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Lipid solutions for injectables
IOI Oleo GmbH - EXCIPIENTS FOR INJECTABLE FORMULATIONS
For injectable formulations, the selection of a pure excipient is key to ensure constant drug product quality, stability, efficacy, and finally patient safety.
IOI Oleo offers formulators a dedicated range of excipient-grade carrier…
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A Oral Fast Dissolving Films Containing Lyophilized Labetalol HCL with Hydroxy Propyl…
Introduction: Labetalol HCL is an antihypertensive drug used to treat high blood pressure in the long term management of angina. Labetalol HCL is readily absorbed after oral administration. Labetalol HCl undergoes considerable hepatic first-pass metabolism due to its lipid-soluble nature.…
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Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis
Rheumatoid arthritis is a chronic autoimmune disease, with the features of recurrent chronic inflammation of synovial tissue, destruction of cartilage, and bone erosion, which further affects joints tissue, organs, and systems, and eventually leads to irreversible joint deformities and body…
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Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of…
Abstract
The importance of lipid-based formulations in addressing solubility and ultimately the bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of literature on lipid excipient chemistry and performance, notably in relation to oxidative stability. While…
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DoE Based Formulation Development and Characterization of Topical Nanoemulgel of Diacerein: In-Vitro…
Diacerein (DCN) is the class II rhein derivative with low oral bioavailability, although it has good anti-osteoarthritic action. Because of the potential to induce adverse effects when taken orally, the current study focused on producing a topical nanoemulgel formulation based on the 32 Box-Behnken…
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Formulation and Evaluation of Transdermal Gel Containing Tacrolimus-Loaded Spanlastics: In Vitro, Ex…
Our goal was to prepare Span 60-based elastic nanovesicles (spanlastics (SPLs)) of tacrolimus (TCR) using the adapted ethanol injection method, characterize them, and evaluate their ability to improve the transdermal permeation of the active substance. The impact of two different concentrations of…
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Towards a better understanding of the role of stabilizers in QESD crystallizations
Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an…
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Structural and thermal analysis of cannabidiol orodispersible formulation
Cannabidiol (CBD) is an alkaloid that can be found in the Cannabis species, currently used in United States of America under the name of Epidiolex®, which was approved by Food and Drug Administration (FDA) for seizures treatment. The purpose of this study was to investigate the structural…
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