Pharma Excipients
Propylene Glycol
Potentially harmful excipients in neonatal medications: a multicenter nationwide observational study…
Background
A multicenter investigation of neonate exposure to potentially harmful excipients (PHEs) in neonatal intensive care units (NICUs) in Japan has not been conducted.
Methods
A multicenter nationwide observational study was conducted. Neonate patient demographic data and information on all…
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Oral jelly of metformin hydrochloride – Formulation development using Design of Experiments and…
Metformin hydrochloride is an antihyperglycemic drug, for treatment of type 2 diabetes. The therapeutic dose range is 250 mg–1000 mg in immediate release form. Due to bulky nature of the tablets, there may be difficulty in swallowing to some patients, especially for geriatric patients. A few liquid…
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Removal of azithromycin from aqueous bulk solution using water/ethanol/transcutol/capryol-90 green…
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion. The drug is identified as potential pharmaceutical drug for detrimental effect on flora and fauna of aquatic lives and human health. Green…
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Excipients in the Paediatric Population: A Review
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric…
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Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal…
Fungal infection of the skin is one of the most common dermatological diseases in the world. Gel formulations are among the most suitable dosage forms for topical use to treat cutaneous infection. Nanotechnology is a promising approach to penetrate the deeper skin layers and enhance permeability of…
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Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects
Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product development. The purpose of this study is to determine the potentiality of…
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An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery…
Polyethylene glycols (PEGs) and PEG derivatives are used in a range of cosmetic and pharmaceutical products. However, few studies have investigated the influence of PEGs and their related derivatives on skin permeation, especially when combined with other solvents. Previously, we reported…
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The progress on sulfhydryl modified polymers with regard to synthesis, characterization and…
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the…
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What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
by Eccles, R. What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?. Lung (2020). https://doi.org/10.1007/s00408-020-00390-x
Most medicines are white bitter powders that are formulated as tablets and capsules but cough medicines are an exception where the taste and…
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Dermal Pharmacokinetics of rivastigmine-loaded liposomes: an Ex vivo- in vivo correlation study
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug delivery and maintain plasma levels within the therapeutic…
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