Pharma Excipients
Propylene Glycol
Dermal Pharmacokinetics of rivastigmine-loaded liposomes: an Ex vivo- in vivo correlation study
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug delivery and maintain plasma levels within the therapeutic…
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Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes:…
The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes.
Specifically, the effect of mannitol (MAN), sorbitol…
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Tuning the Transdermal Delivery of Hydroquinone upon Formulation with Novel Permeation Enhancers
Hydroquinone (HQ) is an anti-hyperpigmentation agent with poor physicochemical stability. HQ formulations are currently elaborated by compounding in local pharmacies. Variability in the characteristics of HQ topical formulations can lead to remarkable differences in terms of their stability,…
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Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Taste Evaluation by Electronic Tongue and Bioavailability Enhancement of Efavirenz
Self-nanoemulsifying drug delivery systems (SNEDDS) are isotropic and thermodynamically stable mixtures of oil, surfactant, co-surfactant, and drug which emulsify spontaneously on contact with aqueous phase under mild agitation. Efavirenz used for treatment of acquired immune deficiency syndrome, is…
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Formulation and evaluation of nasal in situ gel of phenylephrine hydrochloride
24. March 2017
Abstract
In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine hydrochloride was prepared for the treatment of nasal…
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Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo…
21. March 2016
The aim of the present study was to prepare sublingual delivery systems for sildenafil and evaluate its relative bioavailability after sublingual administration in rabbits to attain a rapid onset of action with good efficacy at lower doses. For sublingual application,…
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STEP Database Updated – 40 Excipients now!
25. February 2016
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. It is a user-designed resource developed by European Paediatric Formulation Initiative (EuPFI) and United States Paediatric Formulation Initiative (USPFI) in collaboration for storage and…
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Potentially harmful excipients in neonatal medicines: a pan-European observational study
Objective: We aimed to describe administration of eight potentially harmful excipients of interest (EOI)-parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol, ethanol and benzalkonium chloride-to hospitalised neonates in Europe and to identify risk factors for…
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