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Poloxamer
Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications
Introduction:
Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the…
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Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin
The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various excipients including surfactants, glycerides and waxes, as well as various drug-delivery systems, namely self-emulsifying drug delivery systems (SEDDS), solid…
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Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery systems have been designed to address these issues. One of…
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Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based…
The research study reflects the development of novel voriconazole (VCZ) loaded nanoparticles (NPs) for prolonged delivery for the management of ocular diseases. The in situ ophthalmic gel was prepared by incorporating NPs into carboxymethyl chitosan (CMCh) and poloxamer. The central composite design…
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Proof-of-Concept for Adjusted Surface Energies and Modified Fines as a Novel Concept in Particle…
Currently marketed dry powder inhaler (DPI) medicine lacks drug delivery performance due to insufficient powder dispersion. In carrier-based blends, incomplete drug detachment is typically attributed to excessive adhesion forces between carrier and drug particles. Adding force control agents (FCA)…
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Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor…
Purpose
To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions.
Methods
The osmolality was measured by freezing point depression and vapor pressure for 11 different polymers and surfactants (PEG 3350, 4000,…
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Poloxamer 188 as Surfactant in Biological Formulations – An Alternative for Polysorbate 20/80?
Surfactants are used to stabilize biologics. Especially, polysorbates (Tween® 20 and Tween® 80) dominate the group of surfactants in protein and especially antibody drug products. Since decades drug developers rely on the ethoxylated sorbitan fatty acid ester mixtures to stabilize sensitive…
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The degradation of poloxamer 188 in buffered formulation conditions
Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products due to…
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Optimization of the Micellar-Based In Situ Gelling Systems Posaconazole with Quality by Design (QbD)…
Background: Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is used in the treatment of fungal infections in different ocular tissues by diluting the oral suspension, and successful results were obtained despite low…
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Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular…
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the design, development, and physicochemical characterization of lactoferrin-loaded…
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