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Poloxamer
Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for…
Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low temperatures but gels at higher temperatures, is well suited…
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Solubilization of tadalafil using a tartaric acid and chitosan-based multi-system
Solubilization studies of tadalafil (TDF) have recently improved the dissolution (%) using weak acids and bases in our group. However, the weak acid formulations have a low dissolution (%) of TDF as limitation. Thus, the purpose of this study was to improve the dissolution (%) of TDF over 90% in…
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Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of…
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a…
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Mucoadhesive wafers for buccal delivery of probiotic bacteria: Mechanical properties and enumeration
The development of probiotic formulations has attracted great attention of researchers and industrial community. Their beneficial effects have been demonstrated in human health, and in buccal cavity including prevention of gingivitis, periodontitis, dental caries, oral candidiasis, and…
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Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven…
The purpose of the present study was to optimise diclofenac diethylamine-loaded liquid crystal nanoparticles (LCNPs) using the principles of quality by design. Based on risk assessment, the effect of various formulation variables on the critical quality attributes was investigated. A three-level…
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Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique
The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and polyvinyl pyrrolidone (PVP) K30 and the different characteristics…
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Interaction between mucoadhesive cellulose derivatives and Pluronic F127: investigation on the…
Systems composed of bioadhesive and thermoresponsive polymers can combine in situ gelation with bio/mucoadhesion, enhancing retention of topically applied drugs. The effect of bioadhesive sodium carboxymethylcellulose (NaCMC) and hydroxypropyl methylcellulose cellulose (HPMC) on the properties of…
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Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds
Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but…
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Design of propolis-loaded film forming systems for topical administration: The effect of acrylic…
In situ film forming systems are an alternative to the conventional dosage forms for topical application, performing superior contact and adhesiveness, with a consequent sustained and efficacious therapy. Propolis (PRP) is an extremely versatile natural compound due to its constitutive complexity…
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