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Poloxamer
Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on…
Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their size and its properties, solid lipid nanoparticles as drug delivery carrier have shown…
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Determining the Best Poloxamer Carrier for Thiocolchicoside Solid Dispersions
Industrial pharmacists make many attempts to enhance the solubility of drugs economically. Among the various approaches for enhancing solubility, the solid dispersion (SD) approach is gaining in importance as it is simpler and requires less effort than the other approaches.1
Thiocolchicoside…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Nanomedicine and Chemotherapeutics Drug Delivery: Challenges and Opportunities
Cancer is considered as one of the biggest threats to human worldwide. Researchers suggest that tumour is not just a single mass, it comprises cancerous cells surrounded by noncancerous cells such as immune cells, adipocytes, and cancer stem cells (CSCs) in the extracellular matrix (ECM) contains…
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Design of telmisartan-weak acid solid dispersion to improve its solubility and stability
Telmisartan (TEL), an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. However, low solubility of TEL has resulted in solubilized commercial products with alkalizers. On the contrary, our study aims to improve the solubility and dissolution rate by preparing a…
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Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro…
The improvement of drug solubility is a challenging task in the pharmaceutical industry; moreover, drug stability is also important. This study was designed to improve the dissolution (%) and in vitro anti-inflammation effects of piroxicam (PRX) and maintain its stability using a ternary solid…
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Effect of TPGS surfactant on dissolution sensitivity of a poorly water-soluble drug using high-shear…
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely used in a variety of oral applications to enhance dissolution, solubility, and/or bioavailability of poorly-water soluble drugs. In addition, the use of TPGS could potentially minimize achlorhydric effects typically existing in…
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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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Essential oils: a review on their salient biological activities and major delivery strategies
Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential oils obtained from plant origin only 300 essential oils…
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Dermal Pharmacokinetics of rivastigmine-loaded liposomes: an Ex vivo- in vivo correlation study
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug delivery and maintain plasma levels within the therapeutic…
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