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Poloxamer
Drug Delivery Strategies for Poorly Water-Soluble Silymarin
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly widespread clinical consensus as a natural remedy in the treatment of numerous chronic liver diseases such as cirrhosis and hepatocellular…
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Nanostructured lipidic carriers for dual drug delivery in the management of psoriasis: Systematic…
In the present study, we selected two potential herbal drugs (Smilax china and Salix alba) and developed nano lipidic carriers (NLC) gel for safe and effective topical therapy against psoriasis. Optimization of formulation of NLCs was performed using Box-Behnken design by selecting three input…
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Poloxamer modified florfenicol instant microparticles for improved oral bioavailability
Surfactants can improve the hydrophobicity of poorly water-soluble drugs and increase the stability of microparticles by reducing surface tension. This study describes that surfactant-engineered florfenicol instant microparticles (FIMs) increase bioavailability through a micellar solubilization…
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Thermodynamic Aspects of the Preparation of Amorphous Solid Dispersions of Naringenin with Enhanced…
Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot- Melt Extruder (HME) using the principle of Low-Temperature Solubilization. Before HME, the NRG-POX solid-state interaction was investigated using Flory…
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Kolliphor® P 188 Bio – High purity poloxamer in biologics manufacturing
Manufacture of biologics in suspension cell culture causes damage to the cell membranes (shear stress). The majority of the damage occurs due to agitation from the impellor, and during gas sparging at the bubble layer, regardless of the bioreactor size that is used. Damaged cells in the culture…
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Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant…
The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the matrix of glyceryl behenate and poloxamer (pore former). The solid-state, morphology, and micromeritics of the microspheres were…
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Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan
11. December 2017
Abstract
In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg),…
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Formulation and evaluation of nasal in situ gel of phenylephrine hydrochloride
24. March 2017
Abstract
In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine hydrochloride was prepared for the treatment of nasal…
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Formulation and Evaluation of Mucoadhesive Thermosensitive in situ Gel of Tenofovir Disoproxil…
24. December 2015
Pre-exposure prophylaxis (PrEP) is one of the best preventive strategies in protection against HIV/AIDS. The present research approach is development of novel topical thermosensitive mucoadhesive in situ gel for intravaginal use. Tenofovir disoproxil fumarate (TDF) has…
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