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Polylacticcoglycolic acid – PLGA
Pickering Emulsions: A Novel Tool for Cosmetic Formulators
The manufacturing of stable emulsion is a very important challenge for the cosmetic industry, which has motivated intense research activity for replacing conventional molecular stabilizers with colloidal particles. These allow minimizing the hazards and risks associated with the use of conventional…
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Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)
Poly(lactic-co-glycolic acid) (PLGA) long-acting release depots are effective for extending the duration of action of peptide drugs. We describe efficient organic-solvent-free remote encapsulation based on the capacity of common uncapped PLGA to bind and absorb into the polymer phase net positively…
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In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and…
Development of Level A in vitro-in vivo correlations (IVIVCs) remains challenging for complex long-acting parenterals, such as poly(lactic-co-glycolic acid) PLGA microspheres. The nature of the PLGA polymer excipient has a dominant influence on the performance of PLGA microspheres. These microsphere…
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Transformation of nanoparticles into compacts: A study on PLGA and celecoxib nanoparticles
Oral delivery of nanoparticles possesses many advantages for delivery of active pharmaceutical ingredients (APIs) to the gastrointestinal tract. However, the poor physical stability of nanoparticles in liquid state is often a challenge. Removing water from the nanosuspensions and transforming the…
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PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of…
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Development of curcumin and docetaxel co-loaded actively targeted PLGA nanoparticles to overcome…
The aims of this study were to develop and characterize curcumin (CCM) and docetaxel (DTX) co-loaded poly lactide-co-glycolide (PLGA) nanoparticles (NPs) to overcome blood brain barrier. The cytotoxicity of the obtained curcumin and docetaxel co-loaded polysorbate 80 coated PLGA NPs were studied in…
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PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up
Nanomedicines based on poly(lactic-co-glycolic acid) (PLGA) carriers offer tremendous opportunities for biomedical research. Although several PLGA-based systems have already been approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA), and are widely used in…
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Enhancement of cytotoxicity of diallyl disulfide toward colon cancer by Eudragit S100/PLGA…
According to WHO cancer is the second leading cause of death globally, amounting to about 1 in 6 deaths. Among these, colon cancer is the third leading cause of mortalities worldwide. Current measures for cancer treatment: chemotherapy, radiation, and surgery are accompanied by myriad side effects.…
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Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed…
Polymeric nanoparticles (NPs) are recognized as potential delivery vehicles for vaccines. PLGA is a biocompatible polymer synonymous with polymeric NPs, which can be coated with other polymers such as chitosan that has intrinsic adjuvant properties as well as mucoadhesive properties. Numerous…
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Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug…
05. February 2016
The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which…
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