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Polymers
pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria to the colon remains a challenge. Furthermore, current oral formulations, such as lyophilized bacterial capsules or tablets, are produced using processes that can decrease…
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Comprehensive Evaluation of Polymer Types and Ratios in Spray-Dried Dispersions: Compaction,…
Abstract
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet form. However, the influence of common polymers and drug loading on the manufacturability of ASD…
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3D Printing Emerging Technologies and Functionality of Polymeric Excipients in Drug Product…
See the new book, edited by Michael A. Repka, Nigel Langley
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D printing
Thorough short text and guide for use on the…
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Viatel™ Bioresorbable Polymers – by Ashland
Ashland is a premier global specialty chemicals company serving customers in a wide range of consumer and industrial markets. With the Viatel™ platform, Ashland offers five families of bioresorbable polymers for parenteral controlled release drug delivery systems and medical devices.
viatel™…
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Polymer selection for amorphous solid dispersion of a new drug candidate by investigation of drug…
The antitumor drug candidate X-05 is being developed as an innovative anti-lung cancer drug candidate due to its excellent antitumour activity. A Caco-2 cell permeability study and solubility study confirmed that X-05 belonged to BCS class II or IV compounds. Therefore, the main challenge is to…
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Raw Material Variability in Biomanufacturing: A Case Study Using Poloxamer 188
Introduction & Aim
Media for cell culture has evolved from recipes containing plant or animal-derived products, to fully chemically defined (CD) formulations as an effort to reduce variability in bioprocess performance due to raw materials. A critical ingredient, poloxamer 188, has a history…
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Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a…
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Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly soluble drugs and subsequent…
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Comparison of Two Grafted Copolymers, Soluplus and Kollicoat IR, as Solid Dispersion Carriers of…
Arteether (ART), an antimalarial drug, belongs to BCS class II and has very low oral bioavailability. Clinically, it is given as a solution in oil by the intramuscular route. Solid dispersion in Soluplus or Kollicoat IR, two commonly used grafted copolymers, may improve its in vitro dissolution and…
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A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin:…
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment. So, this study aimed to develop an intelligent…
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