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Polymers
Electroactive Polymers for On-Demand Drug Release
Abstract
Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of daily life. Conductive polymers (CPs) are an emerging group of polymers that possess metal-like…
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Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs:…
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, with drawbacks such as pain and needle waste. To overcome these limitations, microneedle technology is…
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Mucoadhesive Pentoxyfylline Microsphere for Non-Invasive Nasal Drug Delivery
The aim of this study was to formulate and evaluate mucoadhesive sodium alginate microspheres for nasal administration of Pentoxifylline to avoid first-pass metabolism. Microspheres were prepared using an ionic gelation process using a 23 -factorial design. We investigated the effects of several…
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Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive…
Abstract
The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. The tableting machine was equipped with a thermally controlled die to mimic the heat…
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Comprehensive review of Pluronic® polymers of different shapes with prominent applications in…
Abstract
In this review, we have highlighted different types of Pluronic® polymers for prominent photodynamic therapy (PDT) applications. To begin with, we have provided the definition and mechanism of PDT and enumerate its advantages over other frequently used therapeutic modalities. We have also…
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Exploring the Potential of pH-Sensitive Polymers in Targeted Drug Delivery
The pH-sensitive polymers have attained significant attention in the arena of targeted drug delivery (TDD) because of their exceptional capability to respond to alteration in pH in various physiological environments. This attribute aids pH-sensitive polymers to act as smart carriers for therapeutic…
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Suitability of Wurster-Fluid Bed technique for functional Eudragit L-100 coating on tablet cores
Introduction
Film coating of solid dosage forms in pharmaceutical manufacturing is carried out using range of equipment, process parameters and coating formulations to achieve the quality target profile of the dosage form. Besides for aesthetic reasons, film coatings are mostly applied to modify…
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MeltSerts Technology (Brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development,…
The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori…
Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in 15–20% since the barriers of the oral route decrease the…
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The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of…
The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate these results with those of a surface roughness analysis.…
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