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Polymers
Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties…
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed excipient properties. The tablet press was equipped with a…
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Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline…
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Conceptual stabilizer selection for nanomilling based on dispersibility parameters
The choice of stabilizers to prevent particle agglomeration during nanomilling is an elaborate process which is often based on empirical rules and experience. Usually, extensive screening studies are required to find an appropriate stabilizing additive. The present study shows how the selection of…
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Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative…
Purpose
The oral administration of drugs is usually the most convenient, economical, and preferred route for patients. Chitosan is a natural polymer that is biocompatible and possesses good mucoadhesion properties and has been proposed for various biomedical applications such as scaffolds in tissue…
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Screening and optimization of supercritical fluid process for the preparation of albendazole solid…
Solid dispersion (SD) technology has been proved to be one of the most successful techniques to enhance aqueous solubility of poorly-water soluble drugs. Supercritical fluid (SCF) using carbon dioxide (CO2) became attractive due to its own advantages, including non-toxic, low temperature required,…
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Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition…
Introduction
Cannabidiol (CBD) is a promising non-psychoactive cannabinoid that shows several clinical outcomes. Commercially, this molecule is used in Epidiolex® (Greenwich Biosciences, Inc), a Food and Drug Administration (FDA)-approved drug to treat Lennox-Gastaut and Dravet syndromes,…
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Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for…
Amorphous solid dispersions (ASD) represent a viable formulation strategy to improve dissolution and bioavailability of poorly soluble drugs. Our study aimed to evaluate the feasibility and potential role of hydrogenated phospholipid (HPL) as a matrix material and solubilizing additive for binary…
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Spray drying robot for high-throughput combinatorial fabrication of multicomponent solid dispersions
During the development of pharmaceutical spray-dried formulations, many samples must be prepared for physico-chemical characterisation and dissolution testing by systematically varying parameters such as drug loading or the grades and ratios of excipients (polymers, surfactants, etc.). When spray…
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Lipid based formulations as supersaturating oral delivery systems: from current to future industrial…
Lipid-based formulations, in particular supersaturated lipid-based formulations, are important delivery approaches when formulating challenging compounds, as especially low water-soluble compounds profit from delivery in a pre-dissolved state. In this article, the classification of lipid-based…
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The balance of physical stability and drug release in ternary fenofibrate/HPC/Eudragit L100-55…
Introduction
Amorphous solid dispersions are state-of the art enabling technique for poorly water soluble active pharmaceutical ingredients (APIs). In an ASD, the API is molecularly dissolved in a suitable polymer matrix that stabilizes the amorphous state during storage against recrystallization…
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